Tempany C M, Partin A W, Zerhouni E A, Zinreich S J, Walsh P C
Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland.
Prostate. 1993;22(1):39-42. doi: 10.1002/pros.2990220106.
To determine the influence of androgen deprivation induced by the potent 5 alpha-reductase inhibitor finasteride on the volume of the zones of the prostate, 20 symptomatic men with established BPH were randomized to one of three groups: placebo, finasteride 1 mg, and finasteride 5 mg/day. The volume of the entire prostate gland, periurethral zone, and peripheral zone and the seminal vesicles were determined by three dimensional reconstructions of magnetic resonance contoured images of the prostate. There was no significant difference between the results achieved with 1 and 5 mg of finasteride per day; thus the results in these two groups were combined. In the placebo group there was no significant change in the volume of any structure. Following treatment for 1 year with finasteride there was a significant (P < 0.02) 17% decrease in total gland size (11.5 +/- 3.2 cc). Similarly, there was a significant (P < 0.02) 17% decrease in total gland size (11.5 +/- 3.2 cc). Similarly, there was a significant (P < 0.03) decrease in the size of the periurethral zone of the prostate (6.2 +/- 3 cc). Although there was also a decrease in the size of the peripheral zone of the prostate (2.8 +/- 1.2 cc) this did not reach statistical significance. There was no significant change in the volume of the seminal vesicles. These findings indicate for the first time that androgen deprivation induces a significant decrease in the size of the periurethral zone of the prostate in men with established BPH.
为确定强效5α-还原酶抑制剂非那雄胺诱导的雄激素剥夺对前列腺各区体积的影响，将20名已确诊良性前列腺增生（BPH）且有症状的男性随机分为三组之一：安慰剂组、1mg非那雄胺组和5mg/天非那雄胺组。通过前列腺磁共振轮廓图像的三维重建来确定整个前列腺腺体、尿道周围区、外周区以及精囊的体积。每天1mg和5mg非那雄胺的治疗结果之间无显著差异；因此将这两组的结果合并。安慰剂组中任何结构的体积均无显著变化。非那雄胺治疗1年后，腺体总体积显著（P<0.02）减小17%（11.5±3.2立方厘米）。同样，前列腺尿道周围区的大小也显著（P<0.03）减小（6.2±3立方厘米）。虽然前列腺外周区的大小也有所减小（2.8±1.2立方厘米），但未达到统计学显著性。精囊体积无显著变化。这些发现首次表明，雄激素剥夺可使已确诊BPH的男性前列腺尿道周围区的大小显著减小。
