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The GABAA receptor channel mediated chloride ion translocation through the plasma membrane: new insights from 36Cl- ion flux measurements.

作者信息

Kardos J

机构信息

Department of Pharmacodynamics, Central Research Institute for Chemistry, Hungarian Academy of Sciences, Budapest.

出版信息

Synapse. 1993 Jan;13(1):74-93. doi: 10.1002/syn.890130110.

DOI:10.1002/syn.890130110
PMID:7678948
Abstract

GABAA receptors in plasma membranes of neurons are integral oligomers which form chloride channels. The binding of GABA molecules at recognition sites for channel opening triggers a transient increase in transmembrane chloride ion flux. The multiplicity and drug specificity of GABAA receptor, kinetics of channel opening, and desensitization of GABAA receptor and its short- and long-term regulation have been investigated by the use of tracer amounts of the radioactive chloride isotope, 36Cl- ion. Results and new insights from 36Cl- ion flux measurements have been reviewed.

摘要

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