中缝背核中的γ-氨基丁酸释放：在快速眼动睡眠控制中的作用。
GABA release in the dorsal raphe nucleus: role in the control of REM sleep.
作者信息
Nitz D, Siegel J
机构信息
Department of Neuroscience, University of California, Los Angeles 90024, USA.
出版信息
Am J Physiol. 1997 Jul;273(1 Pt 2):R451-5. doi: 10.1152/ajpregu.1997.273.1.R451.
Abstract
The cessation of firing of serotonergic dorsal raphe neurons is a key controlling event of rapid eye movement (REM) sleep. We tested the hypothesis that this cessation of activity is due to gamma-aminobutyric acid (GABA) release using the in vivo microdialysis technique. We found that REM sleep is accompanied by a selective increase in GABA release, but not by a change in glutamate or glycine release in the dorsal raphe nucleus. Microinjection of the GABA agonist muscimol into the dorsal raphe increased REM sleep, although microperfusion of the GABA antagonist picrotoxin blocked REM sleep. These results implicate GABA release as a critical element in the production of the REM sleep state and in the control of discharge in serotonergic neurons across the sleep/wake cycle.
摘要
血清素能中缝背核神经元放电的停止是快速眼动（REM）睡眠的关键控制事件。我们使用体内微透析技术检验了这一假说，即这种活动的停止是由于γ-氨基丁酸（GABA）释放所致。我们发现，REM睡眠伴随着背侧中缝核中GABA释放的选择性增加，但谷氨酸或甘氨酸释放没有变化。向背侧中缝核微量注射GABA激动剂蝇蕈醇可增加REM睡眠，而微量灌注GABA拮抗剂印防己毒素则会阻断REM睡眠。这些结果表明，GABA释放是REM睡眠状态产生以及整个睡眠/觉醒周期中血清素能神经元放电控制的关键因素。
相似文献
1
GABA release in the dorsal raphe nucleus: role in the control of REM sleep.中缝背核中的γ-氨基丁酸释放：在快速眼动睡眠控制中的作用。
Am J Physiol. 1997 Jul;273(1 Pt 2):R451-5. doi: 10.1152/ajpregu.1997.273.1.R451.
2
GABA release in the locus coeruleus as a function of sleep/wake state.蓝斑中γ-氨基丁酸（GABA）的释放作为睡眠/觉醒状态的函数。
Neuroscience. 1997 Jun;78(3):795-801. doi: 10.1016/s0306-4522(96)00549-0.
3
GABA in pedunculopontine tegmentum increases rapid eye movement sleep in freely moving rats: possible role of GABA-ergic inputs from substantia nigra pars reticulata.脑桥被盖腹侧部的 GABA 增加自由活动大鼠的快速眼动睡眠：来自黑质网状部的 GABA 能传入的可能作用。
Neuroscience. 2009 Dec 1;164(2):404-14. doi: 10.1016/j.neuroscience.2009.08.025. Epub 2009 Aug 18.
4
State-dependent changes in glutamate, glycine, GABA, and dopamine levels in cat lumbar spinal cord.猫腰段脊髓中谷氨酸、甘氨酸、γ-氨基丁酸和多巴胺水平的状态依赖性变化。
J Neurophysiol. 2008 Aug;100(2):598-608. doi: 10.1152/jn.01231.2007. Epub 2008 Mar 19.
5
Effects of the 5-HT(7) receptor antagonist SB-269970 microinjected into the dorsal raphe nucleus on REM sleep in the rat.向大鼠中缝背核微量注射5-羟色胺（7）受体拮抗剂SB-269970对快速眼动睡眠的影响。
Behav Brain Res. 2006 Feb 28;167(2):245-50. doi: 10.1016/j.bbr.2005.09.025. Epub 2005 Nov 11.
6
Differentiation of presumed serotonergic dorsal raphe neurons in relation to behavior and wake-sleep states.假定的5-羟色胺能中缝背核神经元与行为及觉醒-睡眠状态的分化
Neuroscience. 2001;104(4):1141-55. doi: 10.1016/s0306-4522(01)00103-8.
7
The role of dorsal raphe nucleus serotonergic and non-serotonergic neurons, and of their receptors, in regulating waking and rapid eye movement (REM) sleep.中缝背核 5-羟色胺能和非 5-羟色胺能神经元及其受体在调节觉醒和快速眼动（REM）睡眠中的作用。
Sleep Med Rev. 2010 Oct;14(5):319-27. doi: 10.1016/j.smrv.2009.10.003. Epub 2010 Feb 12.
8
Role of dorsal raphe neurons in paradoxical sleep generation in the cat: no evidence for a serotonergic mechanism.中缝背核神经元在猫异相睡眠产生中的作用：无5-羟色胺能机制的证据
Eur J Neurosci. 2001 Jan;13(1):103-12.
9
Activation of serotonin 5-HT(1B) receptor in the dorsal raphe nucleus affects REM sleep in the rat.中缝背核中5-羟色胺5-HT(1B)受体的激活会影响大鼠的快速眼动睡眠。
Behav Brain Res. 2010 Jan 5;206(1):8-16. doi: 10.1016/j.bbr.2009.08.037. Epub 2009 Sep 6.
10
Microdialysis perfusion of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) in the dorsal raphe nucleus decreases serotonin release and increases rapid eye movement sleep in the freely moving cat.在自由活动的猫中，向中缝背核微透析灌注8-羟基-2-（二正丙基氨基）四氢萘（8-OH-DPAT）可减少5-羟色胺释放并增加快速眼动睡眠。
J Neurosci. 1996 Apr 15;16(8):2820-8. doi: 10.1523/JNEUROSCI.16-08-02820.1996.
引用本文的文献
1
Chronic Fluoxetine Treatment Desensitizes Serotoninergic Inhibition of GABAergic Inputs and Intrinsic Excitability of Dorsal Raphe Serotonin Neurons.慢性氟西汀治疗使5-羟色胺能对GABA能输入和中缝背5-羟色胺神经元内在兴奋性的抑制作用脱敏。
Brain Sci. 2025 Apr 8;15(4):384. doi: 10.3390/brainsci15040384.
2
Chronic treatment with escitalopram and venlafaxine affects the neuropeptide S pathway differently in adult Wistar rats exposed to maternal separation.在经历母体分离的成年Wistar大鼠中，艾司西酞普兰和文拉法辛的长期治疗对神经肽S通路的影响不同。
AIMS Neurosci. 2022 Sep 13;9(3):395-422. doi: 10.3934/Neuroscience.2022022. eCollection 2022.
3
Erenumab Impact on Sleep Assessed With Questionnaires and Home-Polysomnography in Patients With Migraine: The ERESON Study.依瑞卡单抗对偏头痛患者睡眠的影响：通过问卷调查和家庭多导睡眠图评估——依瑞森研究
Front Neurol. 2022 May 13;13:869677. doi: 10.3389/fneur.2022.869677. eCollection 2022.
4
Microinjection of melanin-concentrating hormone (MCH) into the median raphe nucleus promotes REM sleep in rats.向中缝核微量注射促黑素（MCH）可促进大鼠的快速眼动睡眠。
Sleep Sci. 2021 Jul-Sep;14(3):229-235. doi: 10.5935/1984-0063.20200075.
5
Preoptic Area Modulation of Arousal in Natural and Drug Induced Unconscious States.视前区对自然及药物诱导昏迷状态下觉醒的调节作用
Front Neurosci. 2021 Feb 12;15:644330. doi: 10.3389/fnins.2021.644330. eCollection 2021.
6
REM sleep loss-induced elevated noradrenaline could predispose an individual to psychosomatic disorders: a review focused on proposal for prediction, prevention, and personalized treatment.快速眼动睡眠剥夺导致去甲肾上腺素升高可能使个体易患身心障碍：一项聚焦于预测、预防和个性化治疗建议的综述
EPMA J. 2020 Aug 13;11(4):529-549. doi: 10.1007/s13167-020-00222-1. eCollection 2020 Dec.
7
Transcutaneous Vagus Nerve Stimulation Modulates EEG Microstates and Delta Activity in Healthy Subjects.经皮迷走神经刺激调节健康受试者的脑电图微状态和δ波活动。
Brain Sci. 2020 Sep 25;10(10):668. doi: 10.3390/brainsci10100668.
8
Association of probable REM sleep behavior disorder with pathology and years of contact sports play in chronic traumatic encephalopathy.可能的 REM 睡眠行为障碍与慢性创伤性脑病中的病理学和多年接触性运动的关系。
Acta Neuropathol. 2020 Dec;140(6):851-862. doi: 10.1007/s00401-020-02206-x. Epub 2020 Sep 17.
9
Novel microwire-based biosensor probe for simultaneous real-time measurement of glutamate and GABA dynamics in vitro and in vivo.新型基于微丝的生物传感器探头，用于体外和体内同时实时测量谷氨酸和 GABA 的动态变化。
Sci Rep. 2020 Jul 29;10(1):12777. doi: 10.1038/s41598-020-69636-1.
10
Sleep and Microdialysis: An Experiment and a Systematic Review of Histamine and Several Amino Acids.睡眠与微透析：关于组胺和几种氨基酸的一项实验及系统综述
J Circadian Rhythms. 2019 Jul 3;17:7. doi: 10.5334/jcr.183.
本文引用的文献
1
Amygdaloid control of alerting and behavioral arousal in rats: involvement of serotonergic mechanisms.大鼠杏仁核在警觉和行为唤醒中的调控作用：5-羟色胺能机制的参与
Arch Ital Biol. 1995 Dec;134(1):81-99.
2
Microdialysis perfusion of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) in the dorsal raphe nucleus decreases serotonin release and increases rapid eye movement sleep in the freely moving cat.在自由活动的猫中，向中缝背核微透析灌注8-羟基-2-（二正丙基氨基）四氢萘（8-OH-DPAT）可减少5-羟色胺释放并增加快速眼动睡眠。
J Neurosci. 1996 Apr 15;16(8):2820-8. doi: 10.1523/JNEUROSCI.16-08-02820.1996.
3
Glycine-immunoreactive neurones in the cat brain stem reticular formation.
Neuroreport. 1993 Sep;4(9):1123-6.
4
Projections of the dorsal raphe nucleus to the brainstem: PHA-L analysis in the rat.中缝背核向脑干的投射：大鼠PHA-L分析
J Comp Neurol. 1994 Feb 1;340(1):11-26. doi: 10.1002/cne.903400103.
5
Serotonergic and cholinergic inhibition of mesopontine cholinergic neurons controlling REM sleep: an in vitro electrophysiological study.中脑桥脑胆碱能神经元对快速眼动睡眠的5-羟色胺能和胆碱能抑制作用：一项体外电生理研究
Neuroscience. 1994 Mar;59(2):309-30. doi: 10.1016/0306-4522(94)90599-1.
6
Single-unit responses of serotonergic dorsal raphe neurons to 5-HT1A agonist and antagonist drug administration in behaving cats.行为学实验中猫的5-羟色胺能中缝背核神经元对5-HT1A激动剂和拮抗剂给药的单单位反应。
J Pharmacol Exp Ther. 1994 Sep;270(3):1345-58.
7
Behavioral state-related changes of extracellular serotonin concentration in the dorsal raphe nucleus: a microdialysis study in the freely moving cat.中缝背核中细胞外5-羟色胺浓度与行为状态相关的变化：对自由活动猫的微透析研究
Brain Res. 1994 Jun 20;648(2):306-12. doi: 10.1016/0006-8993(94)91132-0.
8
REM-sleep propensity accumulates during 2-h REM-sleep deprivation in the rest period in rats.在大鼠的休息期，快速眼动睡眠倾向在两小时快速眼动睡眠剥夺期间会累积。
Neurosci Lett. 1994 Oct 10;180(1):76-80. doi: 10.1016/0304-3940(94)90917-2.
9
Central administration of two 5-HT receptor agonists: effect on REM sleep initiation and PGO waves.两种5-羟色胺受体激动剂的中枢给药：对快速眼动睡眠起始和脑桥-膝状体-枕叶波的影响。
Pharmacol Biochem Behav. 1994 Sep;49(1):93-100. doi: 10.1016/0091-3057(94)90461-8.
10
Time course of Fos-like immunoreactivity associated with cholinergically induced REM sleep.与胆碱能诱导的快速眼动睡眠相关的Fos样免疫反应的时间进程。
J Neurosci. 1995 May;15(5 Pt 1):3500-8. doi: 10.1523/JNEUROSCI.15-05-03500.1995.
Zotero 插件