马传染性贫血病毒逆转录酶血清抗体的高流行率。

High prevalence of serum antibodies to equine infectious anemia virus reverse transcriptase.

作者信息

DeVico A L, Issel C J, Le Grice S F, Payne S L, Montelaro R C, Sarngadharan M G

机构信息

Department of Cell Biology, Advanced BioScience Laboratories, Kensington, MD 20895.

出版信息

AIDS Res Hum Retroviruses. 1993 Jan;9(1):7-11. doi: 10.1089/aid.1993.9.7.

DOI:10.1089/aid.1993.9.7

PMID:7678974

Abstract

The immunogenicity of the equine infectious anemia virus (EIAV) reverse transcriptase (RT) was examined by immunoblot assay with recombinant EIAV RT. All of the 19 sera from EIAV-infected horses tested contained antibodies that recognized EIAV RT and directly inhibited the polymerase activity of the enzyme. An examination of sera obtained sequentially from two experimentally infected animals revealed that anti-RT antibodies arise early in infection and increase in level. The appearance of the antibodies correlated with progression toward the asymptomatic period of infection.

摘要

采用重组马传染性贫血病毒（EIAV）逆转录酶（RT）通过免疫印迹试验检测EIAV RT的免疫原性。检测的19份来自感染EIAV马匹的血清均含有能识别EIAV RT并直接抑制该酶聚合酶活性的抗体。对两只实验感染动物连续采集的血清进行检测发现，抗RT抗体在感染早期出现且水平升高。抗体的出现与感染向无症状期的进展相关。