抑制钠钾通道的三磷酸腺苷酶诱导大鼠肥大细胞释放组胺。
Histamine release from rat mast cells induced by the inhibition of adenosinetriphosphatase for Na and K channels.
作者信息
Takei M, Endo K, Umeyama A, Shoji N
机构信息
Faculty of Pharmaceutical Science, Tokushima Bunri University, Japan.
出版信息
J Pharm Sci. 1993 Jan;82(1):25-6. doi: 10.1002/jps.2600820106.
PMID:7679144
Abstract
6-Tridecylresorcylic acid (TRA) caused histamine release from rat peritoneal mast cells in a dose-dependent manner. The release of histamine by TRA was also time dependent. On the other hand, high K+ (150 mM) strongly inhibited TRA-induced histamine release from rat mast cells. These results suggest that histamine release from mast cells might be associated with K+ channel activity.
摘要
6-十三烷基间苯二酚（TRA）以剂量依赖性方式引起大鼠腹膜肥大细胞释放组胺。TRA诱导的组胺释放也具有时间依赖性。另一方面，高钾（150 mM）强烈抑制TRA诱导的大鼠肥大细胞组胺释放。这些结果表明，肥大细胞释放组胺可能与钾通道活性有关。
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