Takei M, Burgoyne D L, Andersen R J
Forschungsinstitut Borstel, Germany.
J Pharm Sci. 1994 Sep;83(9):1234-5. doi: 10.1002/jps.2600830909.
In rat peritoneal mass cells induced by anti-immunoglobulin E (anti-IgE), contignasterol (1) inhibited histamine release in a dose-dependent manner. On the other hand, a reduction product of contignasterol (2) did not inhibit histamine release from mast cells induced by anti-IgE.
在由抗免疫球蛋白E(抗IgE)诱导的大鼠腹膜肥大细胞中,邻萜甾醇(1)以剂量依赖的方式抑制组胺释放。另一方面,邻萜甾醇的还原产物(2)不抑制抗IgE诱导的肥大细胞组胺释放。