Rialland X, Pein F, Saint-Andre J P, Flamant F
Laboratoire de Genetique, Centre Hospitalier Regional et Universitaire D'Angers, France.
Med Pediatr Oncol. 1993;21(2):146-9. doi: 10.1002/mpo.2950210213.
A child, who received successful chemotherapy for pneumoblastoma, developed a myelomonocytic leukemia with translocation t(11;19)(q23;p13) 2 years later. Although this leukemia did not present with features generally associated with therapy-related leukemias, we think this hematologic disease to be secondary to previous chemotherapy. Involvement of chromosome 11q23 is common in acute leukemia and seems to be more significantly related to ANLL in young children (M4 and M5 FAB classification). However, our observation and previous reports suggest that this chromosomal abnormality might be more frequent in therapy-related leukemias. The responsibility of etoposide and cisplatin may be discussed in such secondary malignancies.
一名曾接受成功化疗治疗肺母细胞瘤的儿童，两年后发生了伴有t(11;19)(q23;p13)易位的骨髓单核细胞白血病。尽管这种白血病未表现出通常与治疗相关白血病相关的特征，但我们认为这种血液系统疾病继发于先前的化疗。11号染色体q23的受累在急性白血病中很常见，似乎与幼儿急性非淋巴细胞白血病（FAB分类中的M4和M5）关系更显著。然而，我们的观察以及既往报告提示，这种染色体异常在治疗相关白血病中可能更常见。在这种继发性恶性肿瘤中可能需要讨论依托泊苷和顺铂的作用。
