Leifer D, Krainc D, Yu Y T, McDermott J, Breitbart R E, Heng J, Neve R L, Kosofsky B, Nadal-Ginard B, Lipton S A
Department of Neurology, Children's Hospital, Boston, MA.
Proc Natl Acad Sci U S A. 1993 Feb 15;90(4):1546-50. doi: 10.1073/pnas.90.4.1546.
We have cloned cDNA encoding a human transcription factor that belongs to the MEF2 (myocyte-specific enhancer-binding factor 2) subfamily of the MADS (MCM1-agamous-deficiens-serum response factor) gene family. This factor, which we have named MEF2C, binds specifically to the MEF2 element and activates transcription via this element. Specific isoforms of this factor are found exclusively in brain and are robustly expressed by neurons in cerebral cortex. In situ hybridization indicates that the factor is expressed preferentially in certain neuronal layers of cortex and that expression declines during postnatal development. The unusual pattern of expression in brain suggests that this transcription factor may be important in the development of cortical architecture.
我们克隆了编码一种人类转录因子的cDNA，该转录因子属于MADS（MCM1-无配子生殖-缺陷-血清反应因子）基因家族的MEF2（肌细胞特异性增强子结合因子2）亚家族。我们将这个因子命名为MEF2C，它特异性结合MEF2元件并通过该元件激活转录。该因子的特定亚型仅在大脑中发现，并在大脑皮层的神经元中大量表达。原位杂交表明，该因子在皮层的某些神经元层中优先表达，且在出生后发育过程中表达下降。大脑中这种不同寻常的表达模式表明，这种转录因子可能在皮层结构的发育中起重要作用。
