一大类POU结构域调控基因在哺乳动物脑发育中的表达。
Expression of a large family of POU-domain regulatory genes in mammalian brain development.
作者信息
He X, Treacy M N, Simmons D M, Ingraham H A, Swanson L W, Rosenfeld M G
机构信息
Howard Hughes Medical Institute, University of California, San Diego, La Jolla 92093-0613.
出版信息
Nature. 1989 Jul 6;340(6228):35-41. doi: 10.1038/340035a0.
A novel region referred to as the POU-domain is present in two tissue-specific transcription factors, Pit-1 and Oct-2, that activate expression of genes specifying pituitary and lymphocyte phenotypes. We report the identification of multiple new members of a large family of POU-domain genes expressed in adult brain, and document that all the known mammalian POU-domain genes, including Pit-1 and Oct-2, are expressed widely in the developing nervous system.
一种被称为POU结构域的新区域存在于两种组织特异性转录因子Pit-1和Oct-2中，这两种转录因子可激活指定垂体和淋巴细胞表型的基因的表达。我们报告了在成体大脑中表达的POU结构域基因大家族的多个新成员的鉴定，并证明所有已知的哺乳动物POU结构域基因，包括Pit-1和Oct-2，在发育中的神经系统中广泛表达。
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