Bian Y, Jordan A G, Rupp M, Cohn H, McLaughlin C J, Miettinen M
Department of Surgery, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania 19107.
Acta Cytol. 1993 Jan-Feb;37(1):77-82.
Desmoplastic small round cell tumor is a recently described neoplasm with multidirectional differentiation. Although it occurs predominantly in adolescent males as an intraabdominal mass with multiple peritoneal implants, we report a case with primary pleural involvement. The cytologic features correspond to previously reported histologic findings and include tightly cohesive clusters of small round poorly differentiated malignant cells with accompanying desmoplastic stromal cells. Immunohistochemical studies revealed characteristic reactivity to epithelial markers, desmin and one neuroendocrine marker (chromogranin). We believe that together with clinical and immunohistochemical data, desmoplastic small round cell tumor can be diagnosed in effusion or aspiration cytology specimens.
促纤维增生性小圆细胞瘤是一种最近才被描述的具有多向分化的肿瘤。尽管它主要发生于青少年男性，表现为伴有多发腹膜种植的腹内肿块，但我们报告了一例原发性胸膜受累的病例。细胞学特征与先前报道的组织学发现相符，包括紧密聚集的小圆形低分化恶性细胞群以及伴随的促纤维增生性基质细胞。免疫组化研究显示对上皮标记物、结蛋白和一种神经内分泌标记物（嗜铬粒蛋白）具有特征性反应。我们认为，结合临床和免疫组化数据，促纤维增生性小圆细胞瘤可在积液或穿刺细胞学标本中得以诊断。
