Woldemariam D, Howe R C, Ipuge Y, Frommel D
Department of Paediatrics, Faculty of Medicine, Addis Abeba University, Ethiopia.
Ethiop Med J. 1993 Jan;31(1):63-70.
A case of common variable immunodeficiency observed in an Ethiopian 13 year old girl who, from the age of 9 months, suffered from repeated, severe bacterial infections, but overcame viral infections normally, is reported. The immune defect bore upon the terminal stage of the differentiation of the B-lymphocytes, whose number was normal but which were unable to synthesize immunoglobulin in vitro. Replacement therapy with gammaglobulins controlled infection. The differential diagnosis of recurrent bacterial infection in the tropical context and means of early diagnosis are discussed.
报告了一例在一名13岁埃塞俄比亚女孩中观察到的常见变异型免疫缺陷病例。该女孩从9个月大起就反复遭受严重细菌感染，但能正常克服病毒感染。免疫缺陷影响B淋巴细胞分化的终末阶段，其数量正常，但在体外无法合成免疫球蛋白。用丙种球蛋白进行替代疗法可控制感染。讨论了热带地区复发性细菌感染的鉴别诊断及早期诊断方法。
