Lin Li-Hsin, Tsai Chih-Neng, Liu Ming-Fei, Wang Chrong-Reen
Section of Rheumatology and Section of Allergy and Immunology, Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan.
J Microbiol Immunol Infect. 2005 Oct;38(5):358-60.
Several autoimmune diseases have been reported to be associated with common variable immunodeficiency disease (CVID), including rheumatoid arthritis and Sjögren's syndrome. On the other hand, approximately 20-30% of patients with rheumatoid arthritis develop secondary Sjögren's syndrome. A 26-year-old woman had a 6-year history of chronic symmetric polyarthritis and 3-year history of sicca syndrome prior to admission for pneumonia. Rheumatoid arthritis with secondary Sjögren's syndrome had been diagnosed 1 year before. The patient had experienced 3 episodes of pneumonia during the previous 3 years. Markedly depressed serum immunoglobulin levels prompted a suspicion of common variable immunodeficiency, and the impression was confirmed after a series of examinations. Monthly administration of intravenous immunoglobulin (IVIG) alleviated the polyarthritis and improved the sicca syndrome. IVIG replacement therapy was ultimately successful in curing recurrent bacterial infections, chronic polyarthritis, and improving the severity of sicca syndrome.
据报道，几种自身免疫性疾病与普通可变免疫缺陷病（CVID）相关，包括类风湿性关节炎和干燥综合征。另一方面，约20%-30%的类风湿性关节炎患者会发展为继发性干燥综合征。一名26岁女性在因肺炎入院前有6年慢性对称性多关节炎病史和3年干燥综合征病史。1年前已诊断为类风湿性关节炎伴继发性干燥综合征。该患者在过去3年中经历了3次肺炎发作。血清免疫球蛋白水平明显降低引发了对普通可变免疫缺陷的怀疑，一系列检查后确诊。每月静脉注射免疫球蛋白（IVIG）缓解了多关节炎并改善了干燥综合征。IVIG替代疗法最终成功治愈了复发性细菌感染、慢性多关节炎，并改善了干燥综合征的严重程度。
