Schoepp D D, Conn P J
Lilly Research Laboratories, Eli Lilly & Co., Indianapolis, IN 46285.
Trends Pharmacol Sci. 1993 Jan;14(1):13-20. doi: 10.1016/0165-6147(93)90107-u.
Metabotropic glutamate receptors (mGluRs) are a novel family of recently cloned G protein-coupled receptors. These receptors are heterogeneous and coupled to multiple second messenger systems that include increases in phosphoinositide hydrolysis, activation of phospholipase D, decreases in cAMP formation, increases in cAMP formation, and changes in ion channel function. Using the selective mGluR agonist 1-aminocyclopentane-1,3-dicarboxylic acid (1s,3R-ACPD), considerable progress has been made towards understanding the role of this glutamate receptor class in the central nervous system. This article reviews the molecular aspects and pharmacology of mGluRs, and recent studies elucidating their role in brain function and pathology.
代谢型谷氨酸受体（mGluRs）是最近克隆出的一类新型G蛋白偶联受体。这些受体具有异质性，并与多种第二信使系统偶联，包括磷酸肌醇水解增加、磷脂酶D激活、环磷酸腺苷（cAMP）生成减少、cAMP生成增加以及离子通道功能改变。使用选择性mGluR激动剂1-氨基环戊烷-1,3-二羧酸（1s,3R-ACPD），在理解这类谷氨酸受体在中枢神经系统中的作用方面已经取得了相当大的进展。本文综述了mGluRs的分子层面和药理学，以及阐明它们在脑功能和病理学中作用的最新研究。
