Hasegawa T, Shibata T, Hirose T, Seki K, Hizawa K
First Department of Pathology, University of Tokushima School of Medicine, Japan.
Arch Pathol Lab Med. 1993 Mar;117(3):295-8.
We report a case of osteosarcoma with coexpression of epithelial and mesenchymal markers immunohistochemically of the second lumbar vertebra in a 49-year-old man. Histologically, the tumor largely showed typical patterns of osteosarcoma with lacelike osteoid deposition and chondroblastic and fibroblastic areas. Immunoreactivity for osteocalcin (human bone gamma-carboxyglutamic acid-containing protein) was demonstrated in most of these tumor cells. Both primary and recurrent tumors contained areas that were composed of epithelioid cells with an alveolar pattern and a trabecular arrangement that resembled carcinoma. Some of the epithelioid cells gave positive reactions for cytokeratin and epithelial membrane antigen. On extensive examination, no other site of malignancy was detected. There have been a few reports of osteosarcomas with epithelioid cells, but to our knowledge, the immunohistochemical properties of this type of tumor have not been reported previously. This is an unusual case of osteosarcoma with epithelioid features.
我们报告一例49岁男性第二腰椎骨肉瘤，免疫组化显示上皮和间充质标志物共表达。组织学上，肿瘤大体上呈现骨肉瘤的典型模式，有花边状类骨质沉积以及软骨母细胞和成纤维细胞区域。大多数这些肿瘤细胞中显示出骨钙素（人骨含γ-羧基谷氨酸蛋白）的免疫反应性。原发肿瘤和复发肿瘤均包含由具有肺泡样模式和小梁状排列的上皮样细胞组成的区域，类似癌。一些上皮样细胞对细胞角蛋白和上皮膜抗原呈阳性反应。经过全面检查，未发现其他恶性肿瘤部位。有一些关于含上皮样细胞骨肉瘤的报道，但据我们所知，此前尚未报道过此类肿瘤的免疫组化特性。这是一例具有上皮样特征的不寻常骨肉瘤病例。
