van Noesel C J, Lankester A C, van Lier R A
Central Laboratory of The Netherlands Red Cross Blood Transfusion Service, University of Amsterdam.
Immunol Today. 1993 Jan;14(1):8-11. doi: 10.1016/0167-5699(93)90316-d.
Foreign antigens opsonized by complement degradation products may be bound by both the B-cell antigen receptor (BCR) and CR2-CD19 complexes. Under these circumstances, the extensive cytoplasmic tail of CD19 endows the BCR with additional tyrosine kinase activity and with potential docking sites for molecules involved in cell signalling. Here, Carel van Noesel and colleagues argue that cooperation between BCR and CR2-CD19 at both the extra- and intracellular level provide for optimal recognition of antigen and amplification of ensuing intracellular signals.
被补体降解产物调理的外来抗原可同时被B细胞抗原受体（BCR）和CR2-CD19复合物结合。在这种情况下，CD19广泛的胞质尾部赋予BCR额外的酪氨酸激酶活性以及与细胞信号传导相关分子的潜在对接位点。在此，卡雷尔·范·诺塞尔及其同事认为，BCR与CR2-CD19在细胞外和细胞内水平的协同作用可实现对抗原的最佳识别以及随后细胞内信号的放大。
