Roifman C M, Ke S
Division of Immunology/Allergy, Hospital for Sick Children, Toronto, ON, Canada.
Biochem Biophys Res Commun. 1993 Jul 15;194(1):222-5. doi: 10.1006/bbrc.1993.1807.
The B cell antigen receptor, mIg, is part of a multimolecular complex including Ig alpha, Ig beta, and CD19. We provide evidence here that upon ligation of mIg CD19 becomes phosphorylated on tyrosine residues. Further, protein tyrosine kinase lyn, which is activated by the antigen receptor, can be readily co-immunoprecipitated with CD19 suggesting this is the enzyme responsible for the antigen receptor mediated tyrosine phosphorylation of CD19.
B细胞抗原受体mIg是一个多分子复合物的一部分，该复合物包括Igα、Igβ和CD19。我们在此提供证据表明，mIg连接后，CD19的酪氨酸残基会发生磷酸化。此外，被抗原受体激活的蛋白酪氨酸激酶lyn能很容易地与CD19进行共免疫沉淀，这表明它就是负责抗原受体介导的CD19酪氨酸磷酸化的酶。
