Keldysh P L, Dragani T A, Fleischman E W, Konstantinova L N, Perevoschikov A G, Pierotti M A, Della Porta G, Kopnin B P
Department of Cytogenetics, Cancer Research Center, Moscow, Russia.
Genes Chromosomes Cancer. 1993 Jan;6(1):45-50. doi: 10.1002/gcc.2870060109.
Deletions and/or allelic losses of a portion of the long arm of chromosome 11 were discovered by cytogenetic and restriction fragment length polymorphism analyses in 23 of 39 (59%) informative cases of colorectal carcinoma. By comparing the patterns of loss of heterozygosity and chromosome rearrangements in different patients, we could map a common target region to 11q22-23. This region may contain a tumor suppressor gene, the inactivation of which may be involved in the development of tumors of the large intestine. The subgroup of malignancies with 11q alterations seemed to be enriched by tumors that were located in the rectum, that were Dukes' stage A, and that were well differentiated and mucin producing.
通过细胞遗传学和限制性片段长度多态性分析发现，在39例可提供信息的结直肠癌病例中，有23例（59%）存在11号染色体长臂部分片段的缺失和/或等位基因丢失。通过比较不同患者的杂合性缺失模式和染色体重排情况，我们可以将一个共同的靶区域定位到11q22 - 23。该区域可能包含一个肿瘤抑制基因，其失活可能与大肠肿瘤的发生有关。11q改变的恶性肿瘤亚组似乎在位于直肠、处于Dukes A期、高分化且产生黏液的肿瘤中更为富集。
