Correlation between serotonergic measures in cerebrospinal fluid and blood of subhuman primate.
作者信息
Yan D, Urano T, Pietraszek M H, Shimoyama I, Uemura K, Kojima Y, Sakakibara K, Serizawa K, Takada Y, Takada A
机构信息
Department of Physiology, Hamamatsu University School of Medicine, Handa-cho, Japan.
出版信息
Life Sci. 1993;52(8):745-9. doi: 10.1016/0024-3205(93)90237-w.
The relationship between the concentration of serotonin (5-hydroxytryptamine; 5-HT), its precursor; tryptophan (Trp) and the main metabolite 5-hydroxyindoleacetic acid (5-HIAA) in cerebrospinal fluid (CSF) and blood of monkey have been studied. 5-HT, Trp and 5-HIAA underwent circadian changes in both CSF and blood. Significant correlations were found between 5-HT, 5-HIAA and Trp in CSF and blood. The significance of these findings and their relationship to the use of peripheral serotonergic system as a functional model of the central nervous system are discussed.
Zotero 插件