Scherenberg M, Schubert G E
Institut für Pathologie, Kliniken der Stadt Wuppertal.
Urologe A. 1993 Jan;32(1):38-42.
Histopathological work-up of 47 pure seminomas detected in patients with elevated serum beta-HCG levels was performed as part of the multicentre study on the prognosis of beta-HCG-secreting seminoma. There was no relation between number of specimens and the detection of syncytitrophoblastic giant cells. Invasion of lymph vessels, however, was not found in even 1 case when only 1-10 specimens were examined, whilst when 21-30 specimens were examined this was detected in 33.3%. Invasion of small veins was seen in 8.3% with 1-10 specimens and in 33.3% with 21-30 specimens. That is to say that with increasing number of specimens the rate of detection with be enhanced. To take allow economic factors to be taken account of as well as the clinical demand for comprehensive pathological diagnosis, a diagnostic screening test is recommended. This includes the anatomy of testicular veins and lymph vessels and macroscopic features, to increase the probability that vascular invasion will be detected.
作为β-人绒毛膜促性腺激素（β-HCG）分泌型精原细胞瘤预后多中心研究的一部分，对血清β-HCG水平升高的患者中检测到的47例纯精原细胞瘤进行了组织病理学检查。标本数量与合体滋养层巨细胞的检测之间没有关联。然而，当仅检查1-10个标本时，甚至没有1例发现淋巴管浸润，而当检查21-30个标本时，这一情况在33.3%的病例中被检测到。小静脉浸润在检查1-10个标本时为8.3%，在检查21-30个标本时为33.3%。也就是说，随着标本数量的增加，检测率会提高。为了同时考虑经济因素以及临床对全面病理诊断的需求，建议进行诊断性筛查试验。这包括睾丸静脉和淋巴管的解剖结构以及宏观特征，以提高检测到血管浸润的可能性。
