van de Bor M, Ens-Dokkum M, Schreuder A M, Veen S, Brand R, Verloove-Vanhorick S P
Department of Paediatrics, University Hospital Leiden, The Netherlands.
Dev Med Child Neurol. 1993 Jan;35(1):33-41.
The authors studied the relationship between periventricular-intraventricular haemorrhage in infants of < 32 weeks gestation who had undergone routine cranial ultrasound scanning in the neonatal period, and neurodevelopmental outcome at the age of five years. Of 484 infants enrolled into the study, all 304 survivors were available for follow-up at the age of five years. 85 children had a disability; in 50 of these, the disability caused a handicap. Three children with dilated lateral ventricles and no periventricular-intraventricular haemorrhage were excluded from further analyses. 26 per cent of the infants with severe (grades III/IV) haemorrhage and 67 per cent of the infants with mild (grades I/II) haemorrhage survived the neonatal period. Children with mild haemorrhage had a significantly increased risk of disability (including handicap) at the age of five years.
作者研究了孕周小于32周且在新生儿期接受过常规颅脑超声扫描的婴儿的脑室周围-脑室内出血与5岁时神经发育结局之间的关系。在纳入该研究的484名婴儿中，所有304名存活者在5岁时均可供随访。85名儿童有残疾；其中50名儿童的残疾导致了功能障碍。3名侧脑室扩张但无脑室周围-脑室内出血的儿童被排除在进一步分析之外。重度（III/IV级）出血的婴儿中有26%、轻度（I/II级）出血的婴儿中有67%存活至新生儿期。轻度出血的儿童在5岁时出现残疾（包括功能障碍）的风险显著增加。
