Pérez-Chiesa Y, Narváez Z
Department of Biology, University of Puerto Rico, Río Piedras 00931.
Mutat Res. 1993 Apr;301(4):207-12. doi: 10.1016/0165-7992(93)90059-5.
The wing spot test of Drosophila melanogaster was done to evaluate the genotoxicity of the antitumor indenoisoquinoline analogues of nitidine chloride and fagaronine chloride in larvae. Both compounds have toxic effects but no statistically significant increase in the frequency of spots was detected with the analogue of nitidine chloride. This strongly suggests that this compound is not mutagenic to Drosophila larvae at the concentrations tested. Results with the analogue of fagaronine chloride were ambiguous. Low mutagenicity was detected in only one of two experiments and in the pooled results at 2 mM but not at 5 mM or 10 mM. These results suggest at best a very weak genotoxic effect but its biological significance needs confirmation by results from other assays.
进行了黑腹果蝇的翅斑试验，以评估氯化两面针碱和氯化白屈菜红碱的抗肿瘤茚并异喹啉类似物对幼虫的遗传毒性。两种化合物均具有毒性作用，但在氯化两面针碱类似物试验中未检测到斑点频率有统计学意义的增加。这有力地表明，在所测试的浓度下，该化合物对果蝇幼虫无致突变性。氯化白屈菜红碱类似物的试验结果不明确。仅在两个实验中的一个以及合并结果中，在2 mM浓度下检测到低致突变性，但在5 mM或10 mM浓度下未检测到。这些结果充其量表明有非常微弱的遗传毒性作用，但其生物学意义需要通过其他试验结果来证实。
