小鼠内向整流钾通道的一级结构与功能表达
Primary structure and functional expression of a mouse inward rectifier potassium channel.
作者信息
Kubo Y, Baldwin T J, Jan Y N, Jan L Y
机构信息
Howard Hughes Medical Institute, University of California, San Francisco 94143-0724.
出版信息
Nature. 1993 Mar 11;362(6416):127-33. doi: 10.1038/362127a0.
A complementary DNA encoding an inward rectifier K+ channel (IRK1) was isolated from a mouse macrophage cell line by expression cloning. This channel conducts inward K+ current below the K+ equilibrium potential but passes little outward K+ current. The IRK1 channel contains only two putative transmembrane segments per subunit and corresponds to the inner core structure of voltage-gated K+ channels. The IRK1 channel and an ATP-regulated K+ channel show extensive sequence similarity and constitute a new superfamily.
通过表达克隆从小鼠巨噬细胞系中分离出一种编码内向整流钾离子通道（IRK1）的互补DNA。该通道在钾离子平衡电位以下传导内向钾离子电流，但向外的钾离子电流很小。IRK1通道每个亚基仅包含两个假定的跨膜片段，与电压门控钾离子通道的内核结构相对应。IRK1通道与一种ATP调节的钾离子通道显示出广泛的序列相似性，并构成一个新的超家族。
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