Horowitz J M
Section of Cell Growth, Regulation and Oncogenesis, Duke University Medical Center, Durham, NC 27710.
Genes Chromosomes Cancer. 1993 Feb;6(2):124-31. doi: 10.1002/gcc.2870060211.
The product of the retinoblastoma gene (RB1) is believed to function as a negative regulator of cell growth. Recent experimental results suggest that RB1 may exert its growth-suppressing activity by regulating the transcription of a variety of growth-related genes, including FOS, MYC, and TGFBI. A series of biochemical and molecular analyses suggest that RB1 indirectly affects gene expression via cell-cycle-regulated interactions with transcription factors, such as E2F and SPI. Determination of the mechanisms regulating such protein-protein interactions and the identification of additional targets of RB1 function will provide vital insights into the role of this tumor-suppressor gene in mammalian cell proliferation.
视网膜母细胞瘤基因（RB1）的产物被认为作为细胞生长的负调节因子发挥作用。最近的实验结果表明，RB1可能通过调节多种与生长相关基因的转录来发挥其生长抑制活性，这些基因包括FOS、MYC和TGFBI。一系列生化和分子分析表明，RB1通过与转录因子（如E2F和SPI）的细胞周期调节相互作用间接影响基因表达。确定调节此类蛋白质-蛋白质相互作用的机制以及鉴定RB1功能的其他靶点，将为这种肿瘤抑制基因在哺乳动物细胞增殖中的作用提供至关重要的见解。
