Gaur A, Fathman C G, Steinman L, Brocke S
Department of Medicine, Stanford University School of Medicine, CA 94305.
J Immunol. 1993 Apr 1;150(7):3062-9.
Superantigens have the ability to stimulate a subset of T cells based upon their expressed TCR beta-chain. It has been demonstrated that the administration of staphylococcal enterotoxin B (SEB) in mice leads to unresponsiveness in V beta 8+ T cells in vivo which are the same T cells that could be stimulated in vitro by this enterotoxin. We present here data on the effect of SEB administration in DBA/2 and (PL/J x SJL)F1 mice on their T cell response to two different T cell determinants, the responses against which are dominated by the use of V beta 8+ T cells. Treatment of mice with SEB not only diminished their primary T cell proliferative response to these determinants, but also was able to effectively reduce the memory T cell response. SEB treatment, however, showed only a modest effect in preventing Ac 1-11-induced experimental autoimmune encephalomyelitis in H-2u mice.
超抗原能够根据表达的TCRβ链刺激一部分T细胞。已经证明，给小鼠注射葡萄球菌肠毒素B（SEB）会导致体内Vβ8 + T细胞无反应，而这些T细胞正是在体外可被这种肠毒素刺激的相同T细胞。我们在此展示了给DBA/2和（PL/J×SJL）F1小鼠注射SEB对其T细胞对两种不同T细胞决定簇反应的影响的数据，针对这两种决定簇的反应主要由Vβ8 + T细胞介导。用SEB处理小鼠不仅会减弱它们对这些决定簇的初始T细胞增殖反应，还能够有效降低记忆T细胞反应。然而，SEB处理在预防H - 2u小鼠中由Ac 1 - 11诱导的实验性自身免疫性脑脊髓炎方面仅显示出适度的效果。
