Lawson S N, Perry M J, Prabhakar E, McCarthy P W
Department of Physiology, Medical School, University of Bristol, UK.
Brain Res Bull. 1993;30(3-4):239-43. doi: 10.1016/0361-9230(93)90250-f.
This paper reviews and provides new data on the relationship of the peptide content in rat dorsal root ganglion (DRG) neurons to a) the neurofilament content of the soma and b) the conduction velocities of the fibres. The latter involved intracellular recordings made in vitro followed by dye injection and immunocytochemistry. Because neurofilament-poor DRG neurones have C-fibres, and A-fibre neurones are neurofilament rich, the soma neurofilament content of peptide containing neurones allowed predictions to be made about their conduction velocity ranges. Substance P-like immunoreactive (SP-LI) neurones were mostly small, neurofilament poor, but a few (15%) were neurofilament rich. From conduction velocity measurements, about half the C-fibre neurones studied and 10% of A delta-neurones but no A alpha/beta-neurones showed SP-LI. CGRP-LI neurones were also mainly neurofilament poor neurones, but 32% were neurofilament rich, including small, medium, and large neurones. Fibres of CGRP-LI neurones conducted in the C, A delta or A alpha/beta ranges. Neurones with somatostatin-LI (SOM-LI) were all neurofilament poor; preliminary data is consistent with SOM-LI neurones having C-fibres.
本文回顾并提供了关于大鼠背根神经节（DRG）神经元中肽含量与以下两方面关系的新数据：a）胞体的神经丝含量；b）纤维的传导速度。后者涉及体外进行的细胞内记录，随后进行染料注射和免疫细胞化学研究。由于神经丝含量少的DRG神经元具有C纤维，而A纤维神经元神经丝含量丰富，因此含肽神经元的胞体神经丝含量能够对其传导速度范围进行预测。P物质样免疫反应性（SP-LI）神经元大多体积小、神经丝含量少，但有少数（15%）神经丝含量丰富。根据传导速度测量结果，所研究的C纤维神经元中约一半、Aδ神经元的10%显示出SP-LI，但Aα/β神经元未显示。降钙素基因相关肽样免疫反应性（CGRP-LI）神经元也主要是神经丝含量少的神经元，但32%神经丝含量丰富，包括小、中、大神经元。CGRP-LI神经元的纤维传导速度在C、Aδ或Aα/β范围内。具有生长抑素样免疫反应性（SOM-LI）的神经元均神经丝含量少；初步数据表明SOM-LI神经元具有C纤维。
