Schäfer W, Friebe W G, Leinert H, Mertens A, Poll T, von der Saal W, Zilch H, Nuber B, Ziegler M L
Boehringer Mannheim GmbH, Chemical Research Department, Germany.
J Med Chem. 1993 Mar 19;36(6):726-32. doi: 10.1021/jm00058a009.
The structural features of a new class of non-nucleoside HIV-1 reverse transcriptase inhibitors (3) are presented. Comparison of the structural and electronic properties with those of TIBO (1) and Nevirapine (2) yields a common three-dimensional model. This model permits the improvement of the lead compound 3 by chemical modification (5,6). Additionally, two new types of inhibitors (4, 7) with similar biological activity can be derived from this model. The structure of the new compounds, including their absolute configuration, are determined by X-ray crystallography.
