Mitchell D C, Prince M R, Frisoli J K, Smith R E, Wood R F
Professorial Surgical Unit, St. Bartholomew's Hospital, London, United Kingdom.
Lasers Surg Med. 1993;13(2):149-57. doi: 10.1002/lsm.1900130202.
The yellow color of atherosclerotic plaque is due to the presence of carotenoids, which absorb light between 430-530 nm and account for the preferential ablation of plaque by the pulsed dye laser operating at 480 nm. This study was designed to examine tissue uptake of beta-carotene and the effect of uptake on arterial plaque ablation. Forty-two atherosclerotic NZW rabbits were given intravenous beta-carotene at a dose of 40 mg/kg, twice weekly and killed between 1 hour and 28 days after the initial injection. beta-carotene was not detected in control specimens but was significantly greater in plaque than in normal wall at all time points following beta-carotene injection (P < 0.04 Mann Whitney U test). The ablation threshold was significantly lower in beta-carotene treated plaque than in untreated plaque or normal arterial wall (P < 0.01, Fisher's exact test). In this model beta-carotene is preferentially taken up into arterial plaque, resulting in increased absorption of laser radiation at 480 nm and enhanced tissue ablation.
动脉粥样硬化斑块的黄色是由于类胡萝卜素的存在，类胡萝卜素吸收430 - 530纳米之间的光，这也是脉冲染料激光在480纳米波长下对斑块进行选择性消融的原因。本研究旨在检测β-胡萝卜素在组织中的摄取情况以及摄取对动脉斑块消融的影响。给42只患有动脉粥样硬化的新西兰白兔静脉注射β-胡萝卜素，剂量为40毫克/千克，每周两次，并在首次注射后1小时至28天内处死。在对照标本中未检测到β-胡萝卜素，但在注射β-胡萝卜素后的所有时间点，斑块中的β-胡萝卜素含量均显著高于正常血管壁（曼-惠特尼U检验，P < 0.04）。经β-胡萝卜素处理的斑块的消融阈值显著低于未处理的斑块或正常动脉壁（费舍尔精确检验，P < 0.01）。在该模型中，β-胡萝卜素优先被摄取到动脉斑块中，导致在480纳米波长下激光辐射吸收增加，组织消融增强。
