Effects of glucosinolate breakdown products on the hepatic biotransformation system in male rats.

The effects of 5-vinyloxazolidine-2-thione (VOT), 1-cyano-3-butene (CYB) and various isothiocyanates on parameters of hepatic phase I and phase II biotransformation were investigated in male rats after oral treatment for 3 consecutive days. The compounds with the exception of CYB caused increases in liver weight and glutathione S-transferase activity. Cytochrome P-450 level and monooxygenase activities were decreased by the isothiocyanates and CYB. Administration of VOT resulted in contrasting response of monooxygenases: reduced aminopyrine N-demethylation and enhanced aniline hydroxylation. Possible mechanisms were discussed.