Haie-Meder C, Pellae-Cosset B, Laplanche A, Lagrange J L, Tuchais C, Nogues C, Arriagada R
Department of Radiotherapy, Institut Gustave-Roussy, Villejuif, France.
Radiother Oncol. 1993 Feb;26(2):111-6. doi: 10.1016/0167-8140(93)90091-l.
In 216 patients with brain metastases two schedules of brain irradiation were compared in a randomized trial: one course of 18 Gy/3 fractions/3 days versus the same fractionation followed by a second course of radiotherapy with a one-month time interval. The second course was identical to the first one or delivered 25 Gy/10 fractions/14 days. No difference in overall survival, nor in the neurologic response or in the incidence of complications was demonstrated. Two clinical factors appeared to be prognostic of the overall survival: the presence of multiple brain metastases and the presence of extracerebral metastases.
在一项随机试验中，对216例脑转移患者的两种脑部放疗方案进行了比较：一个疗程为18 Gy/3次/3天，与相同分割方案后间隔1个月进行第二个疗程的放疗。第二个疗程与第一个疗程相同或为25 Gy/10次/14天。结果显示，总生存期、神经学反应或并发症发生率均无差异。有两个临床因素似乎可预测总生存期：存在多个脑转移和存在脑外转移。
