de Campos-Lima P O, Gavioli R, Zhang Q J, Wallace L E, Dolcetti R, Rowe M, Rickinson A B, Masucci M G
Department of Tumor Biology, Karolinska Institute, Stockholm, Sweden.
Science. 1993 Apr 2;260(5104):98-100. doi: 10.1126/science.7682013.
Cytotoxic T lymphocytes (CTLs) control viral infections by recognizing viral peptides presented by major histocompatibility complex (MHC) class I molecules. Human leukocyte antigen (HLA)-A11-restricted CTLs that recognize peptide residues 416 to 424 of the Epstein-Barr virus (EBV) nuclear antigen-4 frequently dominate EBV-induced responses in A11+ Caucasian donors. This epitope is conserved in type A EBV strains from Caucasians and central African populations, where A11 is relatively infrequent. However, strains from highly A11+ populations in New Guinea carry a lysine-to-threonine mutation at residue 424 that abrogates CTL recognition and binding of the peptide to nascent A11 molecules. The results suggest that evolution of a widespread and genetically stable virus such as EBV is influenced by pressure from MHC-restricted CTL responses.
细胞毒性T淋巴细胞（CTL）通过识别主要组织相容性复合体（MHC）I类分子呈递的病毒肽来控制病毒感染。识别爱泼斯坦-巴尔病毒（EBV）核抗原-4的416至424位肽残基的人类白细胞抗原（HLA）-A11限制性CTL在A11 +白种人供体中经常主导EBV诱导的反应。该表位在来自白种人和中非人群的A型EBV毒株中是保守的，而在这些人群中A11相对较少见。然而，来自新几内亚A11高度阳性人群的毒株在424位残基处发生了赖氨酸到苏氨酸的突变，这消除了CTL对该肽的识别以及该肽与新生A11分子的结合。结果表明，像EBV这样广泛传播且基因稳定的病毒的进化受到MHC限制性CTL反应压力的影响。
