对花园蜗牛（Helix aspersa）已鉴定的中枢神经元的神经药理学研究。

Neuropharmacological studies on identified central neurones of the snail, Helix aspersa.

作者信息

Walker R J, Chen M L, Pedder S, Holden-Dye L, White A R, Sharma R

机构信息

Department of Physiology and Pharmacology, University of Southampton.

出版信息

Zh Vyssh Nerv Deiat Im I P Pavlova. 1993 Jan-Feb;43(1):109-20.

PMID:7682023

Abstract

Central neurones of the snail, Helix aspersa, possess both synaptic and somatic receptors to a wide range of classical transmitters and neuroactive peptides. The range of receptors and the type of response is reasonably constant for a specific neurone. This review will provide data concerning the pharmacology of acetylcholine, serotonin, dopamine, noradrenaline, octopamine, glutamate, GABA and purine receptors on identified neurones. Many of these neurones also respond to neuroactive peptides including molluscan peptides, e g, AMPMLRLamide, LSSFVRIamide, SGQSWRQGRPFamide, FMRFamide; coelenterate peptides, e g, pQGRFamide; echinoderm peptides, e g, GFNSALMFamide; and nematode peptides, e g, KNEFIRFamide, KHEYLRFamide, SDPNFLRFamide. Using this data, the pharmacological profiles of identified neurones will be summarised.

摘要

蜗牛（即褐云玛瑙螺）的中枢神经元拥有针对多种经典递质和神经活性肽的突触受体和体细胞受体。对于特定的神经元而言，受体的范围和反应类型相当稳定。本综述将提供有关已鉴定神经元上乙酰胆碱、5-羟色胺、多巴胺、去甲肾上腺素、章鱼胺、谷氨酸、γ-氨基丁酸和嘌呤受体药理学的数据。这些神经元中的许多也对神经活性肽有反应，包括软体动物肽，如AMPMLRL酰胺、LSSFVRI酰胺、SGQSWRQGRPF酰胺、FMRF酰胺；腔肠动物肽，如pQGRF酰胺；棘皮动物肽，如GFNSALMF酰胺；以及线虫肽，如KNEFIRF酰胺、KHEYLRF酰胺、SDPNFLRF酰胺。利用这些数据，将总结已鉴定神经元的药理学概况。