Dew L A, Owen R G, Mulroy M J
Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta 30912.
Hear Res. 1993 Mar;66(1):99-107. doi: 10.1016/0378-5955(93)90264-2.
In this study we describe changes in the size and shape of auditory hair cells of the alligator lizard in vivo during noise-induced temporary threshold shift. These changes consist of a decrease in cell volume, a decrease in cell length and an increase in cell width. We speculate that these changes are due to relaxation of cytoskeletal contractile elements and osmotic loss of intracellular water. We also describe a decrease in the surface area of the hair cell plasmalemma, and speculate that it is related to the endocytosis and intracellular accumulation of cell membrane during synaptic vesicle recycling. Finally we describe an increase in the endolymphatic surface area of the hair cell, and speculate that this could alter the micromechanics of the stereociliary tuft to attenuate the effective stimulus.
在本研究中，我们描述了钝尾毒蜥在噪声诱导的暂时性阈移过程中，其体内听觉毛细胞大小和形状的变化。这些变化包括细胞体积减小、细胞长度减小以及细胞宽度增加。我们推测这些变化是由于细胞骨架收缩元件的松弛和细胞内水分的渗透性流失所致。我们还描述了毛细胞质膜表面积的减小，并推测这与突触小泡循环过程中细胞膜的内吞作用和细胞内积累有关。最后，我们描述了毛细胞内淋巴表面积的增加，并推测这可能会改变静纤毛束的微力学特性，从而减弱有效刺激。
