Braun S, Askanas V, Engel W K, Ibrahim E N
Ron Stever Tissue Culture Laboratory, Department of Neurology, University of Southern California School of Medicine, Los Angeles.
J Neurochem. 1993 May;60(5):1929-35. doi: 10.1111/j.1471-4159.1993.tb13422.x.
We have studied the effect of long-term treatment with hydrocortisone on the expression of acetylcholine receptors (AChRs) at the neuromuscular junctions of human muscle cultured in monolayer and innervated de novo by fetal rat spinal cord motoneurons. Hydrocortisone increased accumulation of junctional AChRs in a dose- and time-dependent fashion. This increase was due to both decreased degradation and increased synthesis of AChRs. Other glucocorticoids, dexamethasone and prednisolone, exerted similar effects. Our study demonstrates a novel action of glucocorticoids on human junctional AChRs.
我们研究了氢化可的松长期治疗对人肌肉单层培养物神经肌肉接头处乙酰胆碱受体（AChRs）表达的影响，该人肌肉由胎鼠脊髓运动神经元重新支配。氢化可的松以剂量和时间依赖性方式增加接头型AChRs的积累。这种增加是由于AChRs的降解减少和合成增加所致。其他糖皮质激素，地塞米松和泼尼松龙，也有类似作用。我们的研究证明了糖皮质激素对人接头型AChRs有新的作用。
