Piedimonte G, Hoffman J I, Husseini W K, Bertrand C, Snider R M, Desai M C, Petersson G, Nadel J A
Cardiovascular Research Institute, University of California, San Francisco.
J Pharmacol Exp Ther. 1993 Apr;265(1):36-40.
We studied the role of different tachykinin receptors in mediating neurogenic vasodilation in the nasal mucosa of anesthetized pathogen-free rats. Three successive determinations of blood flow were made by injecting radionuclide-labeled microspheres suspended in 70% dextrose into the left ventricle. A selective agonist of the tachykinin NK1 receptor increased nasal blood flow, but neurokinin NK2- and NK3-selective agonists were without effect. The natural agonist of NK1 receptors, substance P (1 microgram/kg), increased nasal blood flow, an effect that was abolished by the selective NK1 receptor antagonist (+)-(2S,3S)-3-(2-methoxybenzylamino)-2-phenylpiperidine (CP-99,994). Capsaicin (25 micrograms/kg), a drug that releases tachykinins from sensory nerves, increased nasal blood flow, and this effect was significantly reduced by CP-99,994. We conclude that a significant component of neurogenic vasodilation in rat nasal mucosa is due to the stimulation of NK1 tachykinin receptors.
我们研究了不同速激肽受体在介导麻醉的无特定病原体大鼠鼻粘膜神经源性血管舒张中的作用。通过将悬浮于70%葡萄糖中的放射性核素标记微球注入左心室，连续三次测定血流量。速激肽NK1受体的选择性激动剂增加了鼻血流量，但神经激肽NK2和NK3选择性激动剂无此作用。NK1受体的天然激动剂P物质（1微克/千克）增加了鼻血流量，该作用被选择性NK1受体拮抗剂(+)-(2S,3S)-3-(2-甲氧基苄基氨基)-2-苯基哌啶（CP-99,994）消除。辣椒素（25微克/千克），一种从感觉神经释放速激肽的药物，增加了鼻血流量，且该作用被CP-99,994显著减弱。我们得出结论，大鼠鼻粘膜神经源性血管舒张的一个重要组成部分是由于NK1速激肽受体受到刺激。
