Sieper J, Braun J, Laitko S, Sörensen H, Wu P, Mielke M, Heesemann J
Medizinische Klinik, Klinikum Steglitz, Freie Universität Berlin.
Z Rheumatol. 1993 Jan-Feb;52(1):19-27.
Undifferentiated oligoarthritis (UOA) resembles clinically reactive arthritis (ReA), but does not fulfill the diagnostic criteria. In 46 patients with UOA, in 16 with ReA, and in 15 with rheumatoid arthritis (RA) the humoral and cellular immune response to the ReA-associated bacteria Chlamydia trachomatis, Yersinia enterocolitica, Shigella flexneri, Salmonella enteritidis, Campylobacter jejuni and Borrelia burgdorferi was investigated in paired samples of synovial fluid and peripheral blood. An antigen-specific lymphocyte proliferation in SF was found in 75% of the ReA and in 39% of UOA patients, but in none with RA. Shigella and Chlamydia in ReA and Yersinia and Chlamydia in UOA were the most frequent stimulating antigens. There was a poor correlation between antigen specific lymphocyte proliferation and specific antibodies. We conclude that these bacteria might have a pathogenetic role, not only in ReA, but also in UOA.
未分化型寡关节炎（UOA）在临床上类似于反应性关节炎（ReA），但不符合诊断标准。对46例UOA患者、16例ReA患者和15例类风湿关节炎（RA）患者，在滑膜液和外周血的配对样本中研究了其对与ReA相关细菌沙眼衣原体、小肠结肠炎耶尔森菌、福氏志贺菌、肠炎沙门菌、空肠弯曲菌和伯氏疏螺旋体的体液免疫和细胞免疫反应。在75%的ReA患者和39%的UOA患者的滑膜液中发现了抗原特异性淋巴细胞增殖，但RA患者均未发现。ReA中的志贺菌和衣原体以及UOA中的耶尔森菌和衣原体是最常见的刺激抗原。抗原特异性淋巴细胞增殖与特异性抗体之间的相关性较差。我们得出结论，这些细菌可能不仅在ReA中，而且在UOA中都具有致病作用。
