Mertens W C, Grignon D J, Romano W
Department of Medical Oncology, London Regional Cancer Centre, Ontario, Canada.
Clin Oncol (R Coll Radiol). 1993;5(2):126-8. doi: 10.1016/s0936-6555(05)80868-4.
Paragangliomas (carotid body tumours, chemodectomas) may arise in any area of the body where sympathetic ganglia are present, including chemoreceptors, the adrenal medulla and retroperitoneal ganglia. Increasing numbers of patients are being reported with vertebral metastases and spinal cord compression for which either decompression laminectomy or external beam radiotherapy, or both, are required. Patients with vertebral metastases may develop progression of disease after radiation therapy. There is little published information on the use of chemotherapy in this clinical situation. We report a case of metastatic paraganglioma complicated by spinal cord compression showing evidence of clinical benefit from chemotherapy after progressive disease and symptoms developed in a region previously treated by radiation therapy.
副神经节瘤（颈动脉体瘤、化学感受器瘤）可发生于身体存在交感神经节的任何部位，包括化学感受器、肾上腺髓质和腹膜后神经节。越来越多的患者被报道出现椎体转移和脊髓压迫，对此需要进行减压性椎板切除术或体外照射放疗，或两者皆需。椎体转移患者在放疗后可能出现疾病进展。关于在这种临床情况下使用化疗的公开信息很少。我们报告一例转移性副神经节瘤合并脊髓压迫的病例，该病例显示在先前接受放疗的区域出现疾病进展和症状后，化疗有临床获益的证据。
