伊洛前列素对慢性脑血管痉挛的作用。

The effect of Iloprost on chronic cerebral vasospasm.

Egemen N, Türker R K, Sandlidilek U, Zorlutuna A, Başkaya M, Bilgiç S, Cağlar S, Unlü A

Department of Neurosurgery, Faculty of Medicine, Ankara University, Turkey.

Gen Pharmacol. 1993 Mar;24(2):403-9. doi: 10.1016/0306-3623(93)90324-q.

Abstract

Experimental chronic cerebral vasospasm induced by subarachnoid haemorrhage (SAH) in rabbits was studied in order to evaluate the efficacy of repeated i.v. infusion of Iloprost (ILO). 2. The mean diameter of the basilar artery of intact animals was calculated as 737.5 +/- 52.8 microns while this value was reduced to 237.5 +/- 22.96 microns after SAH. 3. In the ILO treated group the mean diameter of the basilar artery was significantly increased and found to be 593.75 +/- 64.0 microns. 4. No change was observed in intracranial pressure (ICP) except a slight decrease in mean arterial pressure when relatively higher doses of ILO were used. 5. These results were taken as evidence of the high therapeutic value and low side effects of ILO in the treatment of persisting cerebral vasospasm due to SAH.

摘要

为了评估反复静脉输注伊洛前列素（ILO）的疗效，对兔蛛网膜下腔出血（SAH）诱导的实验性慢性脑血管痉挛进行了研究。2. 完整动物基底动脉的平均直径经计算为737.5±52.8微米，而SAH后该值降至237.5±22.96微米。3. 在ILO治疗组中，基底动脉的平均直径显著增加，为593.75±64.0微米。4. 除使用相对较高剂量的ILO时平均动脉压略有下降外，未观察到颅内压（ICP）有变化。5. 这些结果被视为ILO在治疗SAH所致持续性脑血管痉挛方面具有高治疗价值和低副作用的证据。