Imaizumi S, Shimizu H, Ahmad I, Kaminuma T, Tajima M, Yoshimoto T
Department of Neurosurgery, Isawa Prefectural Hospital, Mizusawa, Japan.
Surg Neurol. 1996 Sep;46(3):263-70; discussion 270-1. doi: 10.1016/0090-3019(96)00048-1.
Calcitonin gene-related peptide (CGRP) is an intrinsic vasodilatory substance contained in perivascular nerve fibers of intracranial arteries. It is suggested that CGRP plays a role in cerebral vasospasm after subarachnoid hemorrhage (SAH).
An experimental SAH was produced by intracisternal injection of arterial blood in rabbits. The animals were treated with intrathecal administration of CGRP solution 3 days after SAH. The degree of vasospasm and the effect of CGRP were evaluated angiographically by measuring the basilar artery diameter.
The basilar artery constricted to 73.0% of the pre-SAH values 3 days after SAH. Fifteen minutes after injection of 10(-10) mol/kg CGRP, the basilar artery dilated to 117.1% (n = 8), which was significantly larger than 67.1% in the vehicle group (n = 8) (p < 0.01). The significant vasodilatory effect of CGRP, compared with the vehicle group, lasted for 6 hours.
Intrathecal administration of CGRP has therapeutic potential for treating cerebral vasospasm.
降钙素基因相关肽（CGRP）是颅内动脉血管周围神经纤维中含有的一种内源性血管舒张物质。有研究表明，CGRP在蛛网膜下腔出血（SAH）后的脑血管痉挛中起作用。
通过向兔脑池内注射动脉血制作实验性SAH模型。SAH后3天对动物进行鞘内注射CGRP溶液治疗。通过测量基底动脉直径，血管造影评估血管痉挛程度和CGRP的作用效果。
SAH后3天，基底动脉收缩至SAH前值的73.0%。注射10(-10) mol/kg CGRP 15分钟后，基底动脉扩张至117.1%（n = 8），显著大于载体组的67.1%（n = 8）（p < 0.01）。与载体组相比，CGRP的显著血管舒张作用持续6小时。
鞘内注射CGRP对治疗脑血管痉挛具有潜在的治疗作用。
