Carico E, French D, Bucci B, Falcioni R, Vecchione A, Mariani-Costantini R
Dipartimento di Medicina Sperimentale, Universita La Sapienza, Rome, Italy.
Gynecol Oncol. 1993 Apr;49(1):61-6. doi: 10.1006/gyno.1993.1087.
Integrin alpha 6 beta 4, a putative laminin receptor, is expressed in normal squamous epithelium and in squamous cell carcinomas. We evaluated by immunohistochemistry the topography of the beta 4 subunit in 35 biopsy samples representative of the sequence from normal exocervical epithelium to invasive squamous cell carcinoma. In normal and metaplastic squamous cervical epithelium, in condylomas, and in squamous epithelium with low-grade dysplasia (CIN 1), beta 4 was detected in basal and parabasal cells. In high-grade CIN (2-3) there was enhanced beta 4 expression and upward shift of beta 4 topography to the whole epithelial thickness. The beta 4 chain was diffusely expressed in most invasive squamous cell carcinomas. These observations suggest that profound alterations in the expression of the alpha 6 beta 4 adhesion glycoprotein occur in the intraepithelial phase of cervical carcinogenesis.
整合素α6β4是一种假定的层粘连蛋白受体，在正常鳞状上皮和鳞状细胞癌中均有表达。我们通过免疫组织化学方法评估了35份活检样本中β4亚基的分布情况，这些样本代表了从正常宫颈外上皮到浸润性鳞状细胞癌的病变序列。在正常和化生的宫颈鳞状上皮、尖锐湿疣以及低度发育异常（CIN 1）的鳞状上皮中，β4在基底细胞和副基底细胞中被检测到。在高级别CIN（2 - 3）中，β4表达增强，且β4分布向上移至整个上皮厚度。β4链在大多数浸润性鳞状细胞癌中呈弥漫性表达。这些观察结果表明，α6β4黏附糖蛋白的表达在宫颈癌发生的上皮内阶段发生了深刻改变。
