Collazos J, Rodríguez J, de Miguel J
Servicio de Medicina Interna, Hospital de Galdácano, Vizcaya.
Rev Clin Esp. 1993 Mar;192(5):214-6.
Serum alpha-fetoprotein (AFP) has been determined in 86 cirrhotic patients who simultaneously underwent a complete clinical and analytical evaluation. 25.6% of patients had increased levels (19.1% of Child A, 21.9% of B and 33.3% of C) without any significative differences between Child groups. A correlation between AFP and some analytical findings has been found, being GPT included among the latter (r = 0.24, p = 0.023). No correlation has been found with different laboratory and clinical data. Our data suggest that hepatocyte lesion and/or regeneration play a role in the raise of AFP, although other mechanisms must be implied. Extremely high values, especially with a non active cirrhosis, hardly could be attribute to it, that is why AFP is still a good marker of malignant degeneration in these patients.
对86例同时接受全面临床和分析评估的肝硬化患者测定了血清甲胎蛋白（AFP）。25.6%的患者AFP水平升高（Child A级患者中占19.1%，B级患者中占21.9%，C级患者中占33.3%），Child分级各组之间无显著差异。已发现AFP与一些分析结果之间存在相关性，谷丙转氨酶（GPT）是其中之一（r = 0.24，p = 0.023）。未发现与不同实验室及临床数据存在相关性。我们的数据表明，肝细胞损伤和/或再生在AFP升高过程中起作用，不过必定还涉及其他机制。极高的AFP值，尤其是在非活动性肝硬化患者中，很难归因于此，这就是为什么AFP仍然是这些患者恶性病变的良好标志物。
