Miller F R
Breast Cancer Biology Program, Michigan Cancer Foundation, Detroit 48201.
Crit Rev Oncog. 1993;4(3):293-311.
The number of viable disseminating cancer cells may be reduced dramatically at each step of the metastatic sequence. Host defense mechanisms may contribute to the reduction in the number of cancer cells able to accomplish each step of metastasis. However, augmentation by host defense mechanisms of the ability to complete metastatic events has been observed. The role of cellular host defense mechanisms in the elimination of disseminating cancer cells at individual steps of metastasis is reviewed.
在转移过程的每一步，存活的播散癌细胞数量可能会大幅减少。宿主防御机制可能有助于减少能够完成转移各步骤的癌细胞数量。然而，也观察到宿主防御机制增强了完成转移事件的能力。本文综述了细胞宿主防御机制在转移各个步骤中清除播散癌细胞的作用。
