Allander S V, Bajalica S, Larsson C, Luthman H, Powell D R, Stern I, Weber G, Zazzi H, Ehrenborg E
Department of Clinical Genetics, Karolinska Institute, Stockholm, Sweden.
Growth Regul. 1993 Mar;3(1):3-5.
The insulin-like growth factor binding proteins (IGFBPs) constitute a structurally related protein family with six known members. We have mapped and regionally localized the genes coding for human IGFBP1, 2, 3, and 4, by in situ hybridization and somatic cell hybrid analysis. The IGFBP2 gene maps to chromosomal region 2q33-q34 whereas the genes for IGFBP1 and 3 are localized in a tail-to-tail fashion on chromosome 7 region p14-p12. The IGFBP4 gene is located in the chromosomal region 17q12-21.1. Structural characterization of the genes coding for IGFBP-1, 2, 3, and 5 showed that the translated parts are divided into four exons. The exons are similar both in size and sequence in all studied genes.
胰岛素样生长因子结合蛋白（IGFBPs）构成了一个结构相关的蛋白家族，已知有六个成员。我们通过原位杂交和体细胞杂交分析，对编码人类IGFBP1、2、3和4的基因进行了定位和区域定位。IGFBP2基因定位于染色体区域2q33 - q34，而IGFBP1和3的基因以尾对尾的方式定位于染色体7区域p14 - p12。IGFBP4基因位于染色体区域17q12 - 21.1。对编码IGFBP - 1、2、3和5的基因的结构特征分析表明，翻译部分被分为四个外显子。在所有研究的基因中，外显子在大小和序列上都相似。
