Gardulf A, Björvell H, Gustafson R, Hammarström L, Smith C I
Department of Clinical Immunology, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden.
Clin Exp Immunol. 1993 May;92(2):200-4. doi: 10.1111/j.1365-2249.1993.tb03380.x.
The life situations of 25 patients with hypogammaglobulinaemia were studied before and after the initiation of subcutaneous replacement therapy by using medical records, data registers and questionnaires (a study and a disease-specific questionnaire, the Sickness Impact Profile and the General Health Rating Index). Before treatment, the patients perceived more dysfunctions with regard to ambulation, mobility, emotional behaviour, social interaction, sleep and rest, household management, work and recreation or pastime activities compared with a Swedish reference group (P = 0.0001). A significant increase in the perceived frequency of infections was also seen in untreated patients compared with a group of healthy individuals (P = 0.0001). After 18 months of weekly subcutaneous infusions of an intramuscular gammaglobulin preparation (100 mg/kg), the patients reported a significantly increased, health-related function and improved self-rated health. A significantly higher pre-infusion IgG level was also found.
通过病历、数据登记册和问卷（一项研究及一份疾病特异性问卷、疾病影响量表和总体健康评定指数），对25例低丙种球蛋白血症患者在开始皮下替代治疗前后的生活状况进行了研究。治疗前，与瑞典参照组相比，患者在行走、活动能力、情绪行为、社交互动、睡眠与休息、家务管理、工作及娱乐或消遣活动方面存在更多功能障碍（P = 0.0001）。与一组健康个体相比，未治疗患者的感染感知频率也显著增加（P = 0.0001）。在每周皮下输注肌肉注射用丙种球蛋白制剂（100 mg/kg）18个月后，患者报告与健康相关的功能显著增强，自我评定的健康状况有所改善。还发现输注前的IgG水平显著更高。
