Hart L G, Evans R W
J Chronic Dis. 1987;40 Suppl 1:117S-136S. doi: 10.1016/s0021-9681(87)80041-3.
This study describes and compares the perceived sickness-related behavioral dysfunction of 859 end-stage renal disease (ESRD) patients from 11 centers according to treatment modality via the Sickness Impact Profile (SIP). The unadjusted functional status of ESRD patients differed significantly by treatment modality. Transplantation patients were least functionally limited followed in order by home dialysis, continuous peritoneal dialysis, and in-center dialysis patients. The largest overall differences were for the sleep and rest, work, recreation and pastimes, and home management SIP categories. Regression analysis revealed that many of the large observed intermodality differences in functional status may have resulted from casemix variations (e.g. age and comorbidity differences). Only SIP score differences between transplantation and other treatment modality patients remained significant following the introduction of casemix controls. Results do not justify choosing one dialysis modality over another because of differences in perceived dysfunction.
本研究通过疾病影响量表（SIP）描述并比较了来自11个中心的859例终末期肾病（ESRD）患者根据治疗方式所感知到的与疾病相关的行为功能障碍。ESRD患者未经调整的功能状态因治疗方式不同而有显著差异。移植患者的功能受限最少，其次依次是家庭透析患者、持续腹膜透析患者和中心透析患者。总体差异最大的是睡眠与休息、工作、娱乐和消遣以及家庭管理这些SIP类别。回归分析表明，在功能状态方面观察到的许多较大的模式间差异可能是由病例组合差异（如年龄和合并症差异）导致的。引入病例组合对照后，仅移植患者与其他治疗方式患者之间的SIP评分差异仍然显著。结果并不支持因感知到的功能障碍差异而选择一种透析方式优于另一种透析方式。
