Rank J, Jensen A G, Skov B, Pedersen L H, Jensen K
Department of Environment, Technology and Social Studies, Roskilde University, Denmark.
Mutat Res. 1993 Jun;300(1):29-36. doi: 10.1016/0165-1218(93)90136-2.
The genotoxic potential of the herbicide Roundup and its active agent, glyphosate isopropylamine salt, was studied in three different assays. No clastogenic effects were found in the mouse bone marrow micronucleus test for either of the two agents. In the Salmonella assay only Roundup was tested. It showed a weak mutagenic effect for the concentrations 360 micrograms/plate in TA98 (without S9) and 720 micrograms/plate in TA100 (with S9). These concentrations are close to the toxic level. The anaphase-telophase Allium test showed no effect for the glyphosate isopropylamine salt, but a significant increase in chromosome aberrations appeared after treatment with Roundup at concentrations of 1.44 and 2.88 mg/l when calculated as glyphosate isopropylamine. The most frequent aberrations observed could be characterized as disturbances of the spindle.
在三种不同的试验中研究了除草剂农达及其活性剂草甘膦异丙胺盐的遗传毒性潜力。在小鼠骨髓微核试验中，两种药剂均未发现致断裂效应。在沙门氏菌试验中，仅对农达进行了测试。在TA98（无S9）中，浓度为360微克/平板时，以及在TA100（有S9）中，浓度为720微克/平板时，农达显示出微弱的诱变效应。这些浓度接近毒性水平。后期 - 末期大蒜试验表明，草甘膦异丙胺盐无影响，但当以草甘膦异丙胺计算时，用浓度为1.44和2.88毫克/升的农达处理后，染色体畸变显著增加。观察到的最常见畸变可表征为纺锤体紊乱。
