Gichner T, Velemínský J, Wagner E D, Plewa M J
Institute of Experimental Botany, Prague, Czech Republic.
Mutat Res. 1993 Jun;300(1):57-61. doi: 10.1016/0165-1218(93)90140-9.
The metabolic inhibitors acetaminophen, 7,8-benzoflavone, and methimazole significantly reduced the mutagenicity of the promutagen N-nitrosodimethylamine in the higher plant Arabidopsis thaliana. In contrast, these metabolic inhibitors had no effect on the mutagenicity of the direct-acting mutagen N-methyl-N'-nitro-N-nitrosoguanidine.
代谢抑制剂对乙酰氨基酚、7,8-苯并黄酮和甲巯咪唑显著降低了前诱变剂N-亚硝基二甲胺在高等植物拟南芥中的诱变性。相比之下,这些代谢抑制剂对直接作用诱变剂N-甲基-N'-硝基-N-亚硝基胍的诱变性没有影响。