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对乙酰氨基酚、7,8-苯并黄酮和甲巯咪唑对拟南芥中N-亚硝基二甲胺诱变的抑制作用。

Inhibitory effects of acetaminophen, 7,8-benzoflavone and methimazole towards N-nitrosodimethylamine mutagenesis in Arabidopsis thaliana.

作者信息

Gichner T, Velemínský J, Wagner E D, Plewa M J

机构信息

Institute of Experimental Botany, Prague, Czech Republic.

出版信息

Mutat Res. 1993 Jun;300(1):57-61. doi: 10.1016/0165-1218(93)90140-9.

DOI:10.1016/0165-1218(93)90140-9
PMID:7683770
Abstract

The metabolic inhibitors acetaminophen, 7,8-benzoflavone, and methimazole significantly reduced the mutagenicity of the promutagen N-nitrosodimethylamine in the higher plant Arabidopsis thaliana. In contrast, these metabolic inhibitors had no effect on the mutagenicity of the direct-acting mutagen N-methyl-N'-nitro-N-nitrosoguanidine.

摘要

代谢抑制剂对乙酰氨基酚、7,8-苯并黄酮和甲巯咪唑显著降低了前诱变剂N-亚硝基二甲胺在高等植物拟南芥中的诱变性。相比之下,这些代谢抑制剂对直接作用诱变剂N-甲基-N'-硝基-N-亚硝基胍的诱变性没有影响。

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