[Eosinophilic cystitis].

Nine cases were diagnosed to be eosinophilic cystitis on the basis of histological criteria and clinical observations were made on these cases. In all cases, a past history of allergic or collagen diseases were revealed. Eosinophils in urine were present in 8 out of 9 cases and allergic tests were then performed. Histamine release from biopsied bladder tissue, incubated with anti-IgE, were first examined and a higher level than control was found. Next, intravesical provocation test (IgE RAST positive allergen was introduced into vesical cavity) revealed the appearance of bladder irritabilities within 30 minutes and release of urinary histamine within 3 hours. In 3 cases, provocation tests by eating food were performed and 2 out of 3 cases showed a positive reaction. These results show that allergy may be related to the development of eosinophilic cystitis in part.