Joling P, Mok K S, de Vries Reilingh G, Wever P J, Cornelis R S, Oskam J P, Henken A M
Agricultural University, Dep. Animal Husbandry, Wageningen, The Netherlands.
Vet Q. 1993 Mar;15(1):9-15. doi: 10.1080/01652176.1993.9694360.
The purpose of this investigation was to establish parameters for the evaluation of immune competence in different swine breeds. Cellular and humoral immune reactivity against keyhole limpet haemocyanin (KLH) was analysed using the lymphocyte stimulation test (LST), a skin allergy test and the IgG response. Various characteristics of the KLH-specific immune response were studied in 988 sows of four breeds. KLH-specific immune responses showed considerable variability. The applied statistical model explained 63 to 73 per cent of this variation. Genetic influences, expressed as the heritability estimate, were rather high for the IgG response (0.33), as well as for the skin reaction (0.26) and the LST (0.41-0.45). A positive correlation between the various immune parameters was found. Selective breeding for immune responsiveness seems to be feasible, but selection for cellular as well as humoral immune reactivity also seems to be possible with KLH as the antigen.
本研究的目的是建立不同猪品种免疫能力评估的参数。使用淋巴细胞刺激试验（LST）、皮肤过敏试验和IgG反应分析了针对钥孔血蓝蛋白（KLH）的细胞免疫和体液免疫反应。在四个品种的988头母猪中研究了KLH特异性免疫反应的各种特征。KLH特异性免疫反应表现出相当大的变异性。所应用的统计模型解释了这种变异的63%至73%。以遗传力估计值表示的遗传影响，对于IgG反应（0.33）、皮肤反应（0.26）和LST（0.41 - 0.45）而言相当高。发现各种免疫参数之间存在正相关。针对免疫反应性进行选择性育种似乎是可行的，而且以KLH作为抗原，针对细胞免疫和体液免疫反应进行选择似乎也是可能的。
