Chakraborty S, Chakraborty A K, Patra S P, Bhattacharya S K
Department of Pathology, North Bengal Medical College, Sushrutanagar, Darjeeling.
J Indian Med Assoc. 1993 Feb;91(2):30-3.
A study was conducted with tissue sections of 60 different suspected tuberculous lesions, obtained by biopsy from 60 patients of different age groups. The tissue sections were fixed with formol saline and stained with haematoxylin and eosin and Ziehl-Neelsen stain. Histological picture of tuberculosis and presence of acid-fast bacilli were studied. Out of 60, 39 sections showed typical tuberculous lesions. Remaining 21 sections presented atypical lesions. Of those 39 typical lesions 17(43%) showed presence of acid-fast bacilli. Among atypical lesions 10(47%) showed presence of acid-fast bacilli. Thus it may be stated that diagnosis of tuberculosis is not confirmed unless acid-fast bacilli is demonstrated in the lesions. Tuberculosis in substantial number of cases produces non-granulomatous atypical lesions, so non-specific inflammation and granulation tissue in histology need Ziehl-Neelsen staining and careful search for acid-fast bacilli should be made to exclude tuberculosis where the disease is common.
对60名不同年龄组患者活检获取的60个不同疑似结核病变的组织切片进行了一项研究。组织切片用甲醛生理盐水固定，并用苏木精和伊红以及齐-尼氏染色法染色。研究了结核病的组织学图像和抗酸杆菌的存在情况。60个切片中，39个显示典型的结核病变。其余21个切片呈现非典型病变。在这39个典型病变中，17个（43%）显示有抗酸杆菌。在非典型病变中，10个（47%）显示有抗酸杆菌。因此可以说，除非在病变中发现抗酸杆菌，否则结核病的诊断不能得到证实。相当数量的病例中，结核病会产生非肉芽肿性非典型病变，所以组织学中的非特异性炎症和肉芽组织需要进行齐-尼氏染色，并应仔细查找抗酸杆菌，以排除在该病常见地区的结核病。
