Hioki O, Watanabe A, Minemura M, Tsuchida T
Third Department of Internal Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan.
J Med. 1993;24(1):35-46.
Serum levels of human hepatocyte growth factor (hHGF) in patients with various liver diseases were determined using an ELISA kit to explore its clinical significance. Significantly high levels of serum hHGF were found in patients with acute hepatitis, fulminant hepatitis, liver cirrhosis, and hepatocellular carcinoma. Increased levels of hHGF were observed during severe liver injury in patients who died of fulminant hepatitis. However, the levels returned to normal during the repair process of liver injury in the surviving cases. In patients with liver cirrhosis, serum hHGF levels were negatively correlated with serum albumin (Alb) levels. These results indicate that serum hHGF levels are not useful for detecting repair processes of the injured liver, but serve as an index of the severity of liver dysfunction in various liver diseases.
使用酶联免疫吸附测定（ELISA）试剂盒测定各种肝病患者血清中人肝细胞生长因子（hHGF）水平，以探讨其临床意义。在急性肝炎、暴发性肝炎、肝硬化和肝细胞癌患者中发现血清hHGF水平显著升高。在死于暴发性肝炎的患者严重肝损伤期间观察到hHGF水平升高。然而，在存活病例的肝损伤修复过程中，这些水平恢复正常。在肝硬化患者中，血清hHGF水平与血清白蛋白（Alb）水平呈负相关。这些结果表明，血清hHGF水平对检测受损肝脏的修复过程无用，但可作为各种肝病中肝功能障碍严重程度的指标。
